"The World's Most Powerful Telescopes" is a research expedition across the southern firmament. The science documentary shows the powerful telescopes of the European Southern Observatory (ESO) in action and gives insight into the discoveries they make. The world's most powerful telescopes can be found atop the highest peaks of northern Chile, amidst the exotic flora and fauna of one of the driest regions on the planet: the Atacama Desert. This is the starting point for a journey to the outer edges of our universe.