The world-famous Greyhound bus is almost as old as the Wild West. It is a symbol of North America, of progress, and of nostalgia. Reporter Studs Terkel travelled 2,000 miles across the United States by Greyhound. From Seattle to Chicago, he observes his fellow-passengers. He meets a number of travelers who appear to be very interesting people: a Native American boxer on his way to his birthplace in Montana, a bar owner who was a bank robber in a former 'career', a 99 year old woman who is still running a busy hotel, and, of course, a pedigree cowboy. The spectator of this film listens to their personal stories, watches the beautiful scenery, and is treated to famous feature film fragments in which the Greyhound bus plays a part. Seven states and two time zones later, he is back in his cinema seat.